The airline last flew nonstop to the U.S. in 2013, when it suspended routes to Los Angeles and Newark amid rising fuel costs.
The property features upgrades to what's touted as the world’s largest hotel lobby, where the sculpture "Eclipse" is complemented by the addition of wood-seating alcoves and a light sculpture with 400 lights.
The airline will launch service between Helsinki and San Francisco next summer.
Plans by Waldorf Astoria and Langham suggest that the city’s luxury epicenter, or at least one hub of activity, is moving about a mile southeast of Nob Hill, to the South of Market district, or SoMa.
The route will operate three times a week and will offer ongoing service from Qingdao to Kunming in southwest China.
The hotel will occupy the first 21 stories of a new tower on Mission Street, about six blocks southwest of the Ferry Building.
United, a fellow Star Alliance member, launched its own service between San Francisco and Singapore two weeks ago.
General meet-and-greet services are offered to departing, arriving and connecting passengers.
The addition of the three properties would increase the company's North American inventory by 60%.
A 350-room Grand Hyatt will have a sushi bar, a rooftop cocktail lounge, an indoor pool and 17,000 square feet of meeting space.